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| Drug Class | Example | Use Case | Notes | | :--- | :--- | :--- | :--- | | SSRI | Fluoxetine (Reconcile®) | Generalized anxiety, compulsive disorders, aggression | 4-6 weeks to efficacy | | TCA | Clomipramine (Clomicalm®) | Separation anxiety | Also treats canine OCD | | SARI | Trazodone | Situational anxiety (vet visits, fireworks) | Fast-acting, short duration | | α₂-agonist | Dexmedetomidine (Sileo®) | Noise aversion (specifically licensed for dogs) | Oromucosal gel |

No veterinary diagnosis is complete without a behavioral assessment, and no behavior modification plan is complete without a thorough medical workup. The two fields are not separate—they are the front and back of the same coin. | Drug Class | Example | Use Case

| Medical Condition | Typical Behavioral Change | Mechanism | | :--- | :--- | :--- | | Osteoarthritis (dogs/cats) | Aggression when touched, reluctance to jump, sleep disturbances | Chronic pain → hypervigilance, irritability | | Dental disease | Dropping food, pawing at mouth, "head shyness" | Oral pain → anticipatory anxiety | | Hyperthyroidism (cats) | Increased vocalization (especially at night), restlessness, aggression | Metabolic excess → anxiety, disorientation | | Urinary tract infection | Inappropriate elimination (outside litter box), straining | Pain/urgency → learned aversion to litter box | | Brain tumor (older dogs) | Circling, loss of housetraining, changed sleep-wake cycles | Neurological compression → cognitive decline | fireworks) | Fast-acting