Table 1: Primary causes of OSA.dll disabled error (n=120 reports)
Less common but notable: Some real-time antivirus software quarantines OSA.dll because it hooks game processes (behavior typical of malware). Windows Defender logs this as "Trojan:Win32/Wacatac.B!ml" – a false positive. The game then literally cannot find the DLL, thus “disabled.”
SKSE64 plugins are compiled against a specific Skyrim EXE build number. OSA.dll from 2021 expects v1.5.97 (SE). If the user updates to AE (v1.6.640), SKSE64’s plugin loader performs a version check and refuses to load the DLL.
A user with Skyrim AE v1.6.640 reported the error. Initial log showed: